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NCT05926765 · ClinicalTrials.gov record · last posted 2026-07-24

A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

Name: A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia — clinical trial record (NCT05926765)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: AQUAx2

StatusActive, Not Recruiting

PhasePhase 2

SponsorMeiraGTx, LLC

Started2023-06-13

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.

Protocol amendment history 3 changes detected by DataLookout

2026-07-25

Trial status changed: Recruiting → Active, Not Recruiting

2026-07-25

Primary completion pushed: 2026-12 → 2027-06

2026-07-25

Completion pushed: 2026-12 → 2027-06

Trial Details

NCT Number	NCT05926765
Lead Sponsor	MeiraGTx, LLC
Conditions	Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
Enrollment	290 participants
Start Date	2023-06-13
Primary Completion	2027-06 (estimated)
Study Completion	2027-06 (estimated)
Updated on ClinicalTrials.gov	2026-07-24