Safety of Low PEEP Maneuvers During ARDS Management

Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown. The aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS

NCT Number	NCT05922969
Lead Sponsor	Centre Hospitalier Universitaire, Amiens Collaborators: Centre Hospitalier VALENCIENNES
Conditions	Acute Respiratory Distress Syndrome, Positive End Expiratory Pressure
Enrollment	50 participants
Start Date	2022-05-28
Primary Completion	2024-11 (estimated)
Study Completion	2024-11 (estimated)
Updated on ClinicalTrials.gov	2024-07-10