Efficacy of NA Combined With PEG-IFN-α2b in the Continuous Versus Pulsed Treatment of Patients With Chronic Hepatitis B

Previous studies have shown that there are alterations in the number and affinity of interferon receptors during interferon therapy and that such alterations recover to varying degrees some time after the end of treatment. It can be conjectured that the rest period of pulsed therapy facilitates the recovery of type I interferon receptors and thus the next round of IFN therapy compared to a continuous regimen of interferon.

NCT Number	NCT05922306
Lead Sponsor	Anhui Medical University Collaborators: The First Affiliated Hospital, University of Science and Technology of China, The Second Hospital of Anhui Medical University, Chaohu Hospital of Anhui Medical University, The First Affiliated Hospital of Bengbu Medical University
Conditions	Hepatitis B, Chronic
Enrollment	1,084 participants
Start Date	2023-07
Primary Completion	2027-06 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2023-06-28