Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.

NCT Number	NCT05918575
Lead Sponsor	Rush University Medical Center Collaborators: Hospital Civil de Guadalajara, Medical College of Wisconsin, The University of Texas Health Science Center, Houston, Central DuPage Hospital
Conditions	Obesity, Morbid, Extubation Failure
Enrollment	250 participants
Start Date	2023-07-10
Primary Completion	2028-07-01 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-07