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Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser

Study acronym: FIREStones
StatusRecruiting
PhasePhase 3
Started2024-01-04
View on ClinicalTrials.gov ↗
Record status
This record was last updated November 24, 2025 (before its estimated April 3, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2025-11-18
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v3
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2026-03-15→2026-04-03
Completion date2026-03-15→2026-04-03
Start dateestimated 2023-12-15→confirmed 2024-01-04
Study sites0→9
2023-11-14
Study Status v2
Primary completion date2026-01-15→2026-03-15
Completion date2026-01-15→2026-03-15
Start date2023-10-15→2023-12-15
2023-10-02
Study Identification, Study Status, Study Description, Study Design, Outcome Measures, Eligibility, Contacts/Locations v1
Eligibility criteria+247 characters
Inclusion Criteria: Patients ≥ 18 years old and < 80 years old With the need to perform a flexible ureteroscopy with destr [...] mply with the requirements of the study Exclusion Criteria: PatientsPersons followingcovered anyby measuresarticles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, minors, and persons subject to a legal presentationprotection measure: guardianship or trusteeship) Contra-indication to Furosemide: Hyper-sensitivity to the a [...] encephalopat [...]
Secondary endpoints3 to 4 entries
UrinaryRate of urinary infection AdverseOpioid consumption Number of participants with adverse events
Primary endpoints1 entry, revised
StoneRate of stone free ratepatients
Study description+1,857 characters
Flexible ureteroscopy is the most common technique to treat kidney stones and is the treatment of choice in France. Kidney stones destruction requires its laser pulverization into small fragments in order to remove them through the ureter or improve their spontaneous expulsion along the urinary trac [...]
Study title-87 characters
[...] ble Ureteroscopy for Destruction of Kidney Stones With Laser: a Randomized Controlled Two-parallel Group Multicenter Trial With Blinding Evaluation
2023-06-14
Original filing
In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous hydration, which has never before been the subject of a specific analysis.
Trial Details
NCT Number NCT05916963
Lead Sponsor University Hospital, Tours
Conditions Kidney Stone
Enrollment 374 participants
Start Date 2024-01-04
Primary Completion 2026-04-03 (estimated)
Study Completion 2026-04-03 (estimated)
Updated on ClinicalTrials.gov 2025-11-24