High-Dose Atorvastatin for Vascular Wall Protection in Thrombectomy Patients

This project investigates the impact of statins on cerebral vascular wall damage after mechanical thrombectomy. The investigators will undertake a multi-center, prospective, parallel-controlled, open-label, superiority randomized controlled study based on past research on intense lipid-lowering intervention trials. Patients undergoing post-thrombectomy will be divided into two groups: the test group and the control group. After surgery, the test group will be given a high dose of atorvastatin (80mg/day), followed by a standard dose (20mg/day). The control group will continue to receive the standard dose of atorvastatin (20mg/day). The investigators will compare the high-resolution vascular wall MRI characteristics (vascular wall enhancement, lumen stenosis rate, and so on) within 3-5 days of the operation, as well as the composite incidence of ischemic stroke, transient ischemic attack, intracranial hemorrhage 1 month postoperatively, and the modified Rankin Score at 90 days.

NCT Number	NCT05912686
Lead Sponsor	Zhongda Hospital
Conditions	Mechanical Thrombectomy, Acute Ischemic Stroke
Enrollment	162 participants
Start Date	2023-07-01
Primary Completion	2025-12-01 (estimated)
Study Completion	2026-07-31 (estimated)
Updated on ClinicalTrials.gov	2023-06-23