the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children

The goal of this clinical trial is to investigate the effect of high caloric oral nutritional supplements on body proportion, weight, linear growth pattern, neuropsychological development level and related health aspects (gut health, immune function, quality of life, etc.) in participants aged 1 to 3 years who are malnourished (underweight and wasting),as well as to evaluate the safety of applying high caloric oral nutritional supplements. Participants will receive nutritional education and daily high caloric oral nutritional supplements(experimental group),or will receive nutritional education and dietary instruction(control group).This study may provide data to support the development of clinical intervention strategies for malnourished Chinese children.

NCT Number	NCT05911893
Lead Sponsor	Children's Hospital of Chongqing Medical University Collaborators: Anhui Provincial Children's Hospital, Baoji Maternity and Child Healthcare Hospital, Chengdu Women's and Children's Central Hospital, Guiyang Maternity and Child Health Care Hospital, Guangzhou Women and Children's Medical Center, Hunan Children's Hospital, Jiangxi Maternal and Child Health Hospital, Kunming Children's Hospital, Nanjing Maternity and Child Health Care Hospital, Children's Hospital of The Capital Institute of Pediatrics, Xianyang Children's Hospital, Nestle Health Science, The First Hospital of Jilin University
Conditions	Malnutrition, Child, Malnourishment, Nutritional Deficiency, Undernutrition
Enrollment	200 participants
Start Date	2024-06-17
Primary Completion	2026-03-10 (estimated)
Study Completion	2026-03-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-18