Clinical Trial

The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability

Study acronym: MnHyperex
Recruiting
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Record status
This record was last updated November 28, 2023 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical stimulation (WPHF NMES) in various populations. The investigators will use WPHF NMES contractions as a model to gain insights into the mechanisms underlying muscle cramps, restless legs syndrome or stroke-induced spasticity as there is evidence that they share common underlying mechanisms. The investigators will then use WPHF NMES as a training modality to improve plantar flexor neuromuscular function in stroke patients by taking advantage of their motoneuronal hyperexcitability.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2023-06-08.
Status change: Not Yet Recruiting → Recruiting 2023-11-27
Trial Details
NCT Number NCT05908214
Lead Sponsor University of Lausanne
Collaborators: Swiss National Science Foundation
Conditions Stroke, Cramp, Restless Legs Syndrome, Healthy Volunteers
Enrollment 110 participants
Start Date 2023-10-01
Primary Completion 2025-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2023-11-28