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Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy

StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated September 19, 2025 (before its estimated February 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Notable Primary and study completion dates: Jun 2025 to Feb 2026v4
  2. Notable Primary endpoint revised
    • Secondary endpoints revised (3)
    v3
  3. Notable Primary endpoint revised
    • Secondary endpoints revised (3)
    • Study description revised
    v2
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket. In the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects. Hyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.
Trial Details
NCT Number NCT05907161
Lead Sponsor University of Ljubljana
Collaborators: University Medical Centre Ljubljana
Conditions
(from sponsor)
Periodontitis
Related terms Periodontitis
Enrollment 45 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov