Renin-guided Hemodynamic Management in Patients With Shock

Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant outcomes, individualized approaches for shock supported by robust evidence are required. This study will be a prospective, multicenter, parallel-group, single-blind, randomized controlled trial. The investigators will randomly assign 800 critically ill patients requiring norepinephrine infusion to the renin-guided or usual care groups. The investigators hypothesize that renin-guided hemodynamic management, compared to usual care, can reduce a composite of mortality and acute kidney injury (AKI) progression in patients requiring vasopressor support.

NCT Number	NCT05898126
Lead Sponsor	Università Vita-Salute San Raffaele
Conditions	Shock
Enrollment	800 participants
Start Date	2025-01-27
Primary Completion	2027-04-28 (estimated)
Study Completion	2027-07-28 (estimated)
Updated on ClinicalTrials.gov	2025-08-06