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Renin-guided Hemodynamic Management in Patients With Shock

Study acronym: RENIN
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Study sites: 2 to 3v7
  2. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 1 to 2
    • Start date changed from estimate of Jan 5, 2025 to Jan 27, 2025
    v6
  3. Start date: Sep 5, 2024 to Jan 5, 2025v5
  4. Start date: Feb 5, 2024 to Sep 5, 2024v4
  5. Start date: Jun 5, 2023 to Feb 5, 2024v3
  6. Phase: Phase 3 to Not applicable
    • Study description expanded, about 1 word
    v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant outcomes, individualized approaches for shock supported by robust evidence are required. This study will be a prospective, multicenter, parallel-group, single-blind, randomized controlled trial. The investigators will randomly assign 800 critically ill patients requiring norepinephrine infusion to the renin-guided or usual care groups. The investigators hypothesize that renin-guided hemodynamic management, compared to usual care, can reduce a composite of mortality and acute kidney injury (AKI) progression in patients requiring vasopressor support.
Trial Details
NCT Number NCT05898126
Lead Sponsor Università Vita-Salute San Raffaele
Conditions
(from sponsor)		 Shock
Related terms Acute Kidney Injury, Shock
Enrollment 800 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov