Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women

Osteoarthritis (degenerative joint disease) and osteoporosis (weak and fragile bones) are common conditions, particularly in women after menopause, and become even more common as we get older. Aging is also associated with sarcopenia, the progressive loss of muscle strength and mass with age. In this three-arm study, the effect of resistance exercise programs with different parameters (such as velocity and load) on various outcomes, including structural changes (bone mineral density, cartilage composition, muscle size), physical function, and biomarkers will be compared.

NCT Number	NCT05889598
Lead Sponsor	Loughborough University Collaborators: Versus Arthritis
Conditions	Osteoporosis, Osteoarthritis
Enrollment	110 participants
Start Date	2022-03-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-21