The PRECISION-T2D Study: Precision Nutrition Study for Type 2 Diabetes

Food plays a crucial role in determining blood glucose levels, especially in people with type 2 diabetes. Precision nutrition, which involves individually tailored dietary interventions, can be a powerful tool in managing blood glucose levels in people with type 2 diabetes. Previous studies found that changes in gut microbiota resulted from the dietary intervention, such as plant-based diet, might subsequently lead to different glycemic responses, and then different health outcomes. In this study, the investigators will characterize the blood glucose dynamics and gut microbiota of individuals with type 2 diabetes. They aim to assess the influence of plant-based diet on gut microbiota; they will also investigate the influence of gut microbiota on glycemic responses. Additionally, a series of individual N-of-1 trails will be integrated to compare the effects of a white bread breakfast and a whole wheat bread breakfast on glucose metabolism at the individual level.

NCT Number	NCT05885828
Lead Sponsor	Westlake University Collaborators: The Third People's Hospital of Hangzhou
Conditions	Type 2 Diabetes
Enrollment	200 participants
Start Date	2023-07-17
Primary Completion	2025-12-31 (estimated)
Study Completion	2033-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-06-13