Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis

Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of adequate volume resuscitation to correct hypovolemia and vasopressor medication to correct hypotension. Recently, relevant studies have shown that sustained tachycardia in sepsis was also related to high mortality, and appropriate control of heart rate could improve prognosis. Ivabradine reduces heart rate directly without a negative inotropic effect through inhibition of the If ionic current，which is absent from the traditional rate control drug (beta-blockers). This is a prospective, multicenter, randomized, open label study designed to compare ivabradine with placebo on the difference of heart rate and haemodynamics in patients with sepsis.

NCT Number	NCT05882708
Lead Sponsor	Second Affiliated Hospital of Guangzhou Medical University Collaborators: The Third Affiliated Hospital of Guangzhou Medical University
Conditions	Sepsis, Ivabradine, Hemodynamics, Heart Rate Control
Enrollment	172 participants
Start Date	2023-06-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-24