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Doxycycline for Helicobacter Pylori Rescue Treatment

StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 30, 2024 (before its estimated October 10, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Dec 10, 2024 to Oct 10, 2025
    • Study completion date: Dec 31, 2024 to Oct 31, 2025
    • Site contact updated
    v4
  2. Re-verified, no change to tracked fieldsv3
  3. Start date: May 16, 2023 to Jun 20, 2023v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy. However, tetracycline is clinically unavailable in China and the high frequency of adverse events of bismuth quadruple therapy often result in poor compliance, which limited the applicability of this recommendation. This study aimed to compare the efficacy and tolerability of a 14-day bismuth-containing quadruple rescue therapy in which tetracycline was replaced by doxycycline.
Trial Details
NCT Number NCT05874570
Lead Sponsor Shanghai Jiao Tong University School of Medicine
Conditions
(from sponsor)		 Helicobacter Pylori Infection
Enrollment 368 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov