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Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.

Study acronym: BOPPP
StatusActive, Not Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Primary endpoint revisedv2 Show 5 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Enrollment target: estimated 1200 to confirmed 763
    • Start date: Jun 1, 2019 to Apr 1, 2019
    • Site details revised
    • Eligibility criteria expanded, about 2 words
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Research has proven that large varices can be treated with beta-blockers (a type of anti-hypertensive medication) to reduce the pressure in the veins. The management of small varices is still uncertain. This study aims to discover if beta blockers can be used in this setting. We hypothesize that beta blockers will reduce the risk of bleeding from small varices from 20% to 10% over a period of 3 years, resulting in significant cost savings to the NHS from better patient outcomes.
Trial Details
NCT Number NCT05872698
Lead Sponsor King's College Hospital NHS Trust
Collaborators: King's College London, Cardiff University, Brighton and Sussex University Hospitals NHS Trust
Conditions
(from sponsor)		 Cirrhosis, Liver, Portal Hypertension, Variceal Hemorrhage, Varices, Esophageal
Related terms Esophageal and Gastric Varices, Hypertension, Portal, Liver Cirrhosis
Enrollment 763 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov