Clinical Trial

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.

Study acronym: BOPPP
Active, Not Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
Research has proven that large varices can be treated with beta-blockers (a type of anti-hypertensive medication) to reduce the pressure in the veins. The management of small varices is still uncertain. This study aims to discover if beta blockers can be used in this setting. We hypothesize that beta blockers will reduce the risk of bleeding from small varices from 20% to 10% over a period of 3 years, resulting in significant cost savings to the NHS from better patient outcomes.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2023-05-23.
Status change: Recruiting → Active, Not Recruiting 2026-04-24
Trial Details
NCT Number NCT05872698
Lead Sponsor King's College Hospital NHS Trust
Collaborators: King's College London, Cardiff University, Brighton and Sussex University Hospitals NHS Trust
Conditions Cirrhosis, Liver, Portal Hypertension, Variceal Hemorrhage, Varices, Esophageal
Enrollment 763 participants
Start Date 2019-04-01
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-05-01