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Challenge Non-Typhoidal Salmonella (CHANTS) Study

Study acronym: CHANTS
StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated May 2, 2025 (before its estimated February 28, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Sep 30, 2024 to Feb 28, 2026
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Jun 13, 2025 to Feb 28, 2026
    • Site details revised
    v3
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Jul 1, 2023 to Aug 31, 2023
    • Eligibility criteria expanded, about 7 words
    • Site details revised
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This protocol describes the challenge non-typhoidal Salmonella (CHANTS) study. This is a first-in-human phase 1, double-blinded, randomised, dose-escalation human infection study, conducted in healthy volunteers aged 18 to 50 years. The primary objective of the study is to perform a dose escalation with two strains (ST19 or ST313) to determine the infectious dose required for 60-75% of volunteers to develop Salmonellosis using a composite diagnostic criterion. The secondary objectives of the study are to describe and compare the clinical and laboratory features following controlled human infection. It is hoped that the successful establishment of an NTS human challenge model can be used in the future to test candidate vaccines for NTS disease.
Trial Details
NCT Number NCT05870150
Lead Sponsor Imperial College Healthcare NHS Trust
Collaborators: University of Oxford, University of Liverpool, PATH, Imperial College London
Conditions
(from sponsor)		 Salmonella Infections, Salmonella Typhimurium, Non-typhoidal Salmonella (NTS), Invasive Non-Typhoidal Salmonella Disease, Communicable Disease, Infections, Bacterial, Enteric Fever (Not Typhoid), Gastroenteritis
Related terms Bacterial Infections, Communicable Diseases, Gastroenteritis, Salmonella Infections, Typhoid Fever
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov