Prediction of the Therapeutic Response in Depression Based on Neuro-computational Modeling Assessment of Motivation

This study aims to better understand the mechanisms of action of antidepressants, but also the neural correlates of motivation deficits. One hundred patients with a moderate to severe major depressive episode will be enrolled in this prospective multicenter study. The objective will be to predict the therapeutic response to two first-line antidepressants on the basis of an early neurocomputational assessment of motivation. Antidepressant treatment will be administered as monotherapy after randomization between two drugs: escitalopram and vortioxetine. Patients will undergo six visits and follow-up for one year. The investigators will combine computer modeling and functional MRI to identify motivational deficits and elucidate their brain correlates before initiation, after 7 days and after 6 months of treatment. 36 healthy volunteers will also be included to allow comparison with patients with depression. They will not receive any treatment.

NCT Number	NCT05866575
Lead Sponsor	Centre Hospitalier St Anne
Conditions	Major Depressive Disorder
Enrollment	136 participants
Start Date	2023-09-12
Primary Completion	2026-10-12 (estimated)
Study Completion	2026-11-12 (estimated)
Updated on ClinicalTrials.gov	2024-07-10