Clinical Trial

Immunogenicity of Yellow Fever Vaccine 17D in Adults With Prior 17D Vaccination

Recruiting Phase 1/2
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Record status
This record was last updated July 31, 2025 (before its estimated November 1, 2025 completion). Its status may not reflect the trial's current state.
Summary
The goal of this clinical trial is to assess the immune response to the yellow fever vaccine 17D in adults with prior 17D vaccination. The main questions this study aims to answer are: * how does prior vaccination affect antibody responses to re-vaccination? * how does prior vaccination affect the immune cell response to re-vaccination? Participants will: * have been previously vaccinated with 17D. * be re-vaccinated with 17D. * provide medical and travel histories. * provide a blood sample prior to vaccination * provide a blood sample approximately every other day for 14 days after vaccination. * provide a blood sample approximately 28 days after vaccination. * complete a daily diary of symptoms following vaccination for 14 days. * report any additional symptoms after 14 days.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-05-10; most recent amendment 2025-07-28.
Status change: Not Yet Recruiting → Recruiting 2023-09-26
Trial Details
NCT Number NCT05859490
Lead Sponsor Oregon Health and Science University
Conditions Yellow Fever, Immunization; Infection
Enrollment 35 participants
Start Date 2023-08-01
Primary Completion 2025-11-01 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-07-31