Clinical Trial

Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy

Study acronym: PEARL
Completed Phase 3
View on ClinicalTrials.gov →
Summary
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial aiming at evaluating the efficacy and safety of intra-arterial recombinant human tissue plasminogen activator (rt-PA) after successful recanalization of acute large vessel occlusion in the anterior circulation by mechanical thrombectomy in improving the 90-day functional outcome.
Protocol Amendment History 3 changes
critical Trial completed 2026-08-13
notable Primary completion moved earlier: 2025-12 -> 2025-01-15 2026-08-13
minor Completion moved earlier: 2025-12 -> 2025-11-01 2026-08-13
Trial Details
NCT Number NCT05856851
Lead Sponsor Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Collaborators: Shenzhen Hospital of Southern Medical University
Conditions Stroke, Acute Ischemic
Enrollment 324 participants
Start Date 2023-08-01
Primary Completion 2025-01-15 (estimated)
Study Completion 2025-11-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-12