Clinical Trial

Perennial Malaria Chemoprevention (PMC) in Côte D'Ivoire

Active, Not Recruiting
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Record status
This record was last updated January 9, 2025 (before its estimated June 2025 completion). Its status may not reflect the trial's current state.
Summary
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study area reporting all doses of SP received and the number of confirmed cases of malaria and anaemia, as well as a prospective active cohort of children who will have seven home visits over an 18-month period. The total number of participants is expected to be approximately 1568 children in the areas served by 19 health centres in Côte d'Ivoire. The results of this study will allow direct evaluation of the protective efficacy of PMC on malaria incidence, severe anaemia, and malaria mortality.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2023-05-03; most recent amendment 2025-01-08.
Status change: Recruiting → Active, Not Recruiting 2025-01-08
Status change: Not Yet Recruiting → Recruiting 2023-08-22
Trial Details
NCT Number NCT05856357
Lead Sponsor London School of Hygiene and Tropical Medicine
Collaborators: Institut National de Santé Publique de Côte d'Ivoire
Conditions Malaria, Anemia
Enrollment 1,568 participants
Start Date 2023-08-11
Primary Completion 2025-06 (estimated)
Study Completion 2025-09 (estimated)
Updated on ClinicalTrials.gov 2025-01-09