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Cardiometabolic Health in First Time Pregnancy

Study acronym: POPPY
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 6 to 7
    • Start date changed from estimate of Jun 2023 to May 24, 2023
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy. This study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.
Trial Details
NCT Number NCT05856318
Lead Sponsor Cambridge University Hospitals NHS Foundation Trust
Collaborators: University of Cambridge, University of Bristol, University College, London, King's College London, Imperial College London, St George's, University of London, University of Glasgow, Wellcome Trust
Conditions
(from sponsor)		 Cardiometabolic Health, Pregnancy Related, Diabetes, Placental; Syndrome, Dysfunction, Heart Diseases
Related terms Diabetes Mellitus, Heart Diseases, Syndrome
Enrollment 3,500 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov