Clinical Trial

SCRT in TNT With or Without Chlorophyllin

Study acronym: SCOTCH
Active, Not Recruiting Phase 2
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Summary
The goal of this clinical trial is to see, if addition of chlorophyllin to neoadjuvant Chemo-radiotherapy can reduce the gastro-intestinal/genitourinary/hematological toxicity rates and improve the quality of life in patient's diagnosed with locally advanced rectal cancer. This is a randomized placebo control trial, wherein participants randomized to Chlorophyllin arm will receive the drug of interest along with the standard treatment. Participants randomized to other arm will receive placebo along with the standard treatment. Researchers will compare the difference between the outcomes from both the arms and will also observe the non-operative management success rates.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2023-05-03; most recent amendment 2025-09-25.
Status change: Recruiting → Active, Not Recruiting 2025-04-07
Status change: Not Yet Recruiting → Recruiting 2023-06-20
Trial Details
NCT Number NCT05856305
Lead Sponsor Tata Memorial Centre
Conditions Rectal Neoplasms
Enrollment 76 participants
Start Date 2023-07-05
Primary Completion 2025-09-09 (estimated)
Study Completion 2027-09-09 (estimated)
Updated on ClinicalTrials.gov 2025-09-26