Clinical Trial

Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

Study acronym: APPOINT
Active, Not Recruiting
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Record status
This record was last updated August 26, 2025 (before its estimated November 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2023-05-02; most recent amendment 2025-08-20.
Trial Details
NCT Number NCT05853068
Lead Sponsor Hospital Universitario de Gran Canaria Doctor Negrín
Collaborators: Rush University Medical Center
Conditions Acute Hypoxemic Respiratory Failure
Enrollment 400 participants
Start Date 2023-04-29
Primary Completion 2025-11-30 (estimated)
Study Completion 2025-11-30 (estimated)
Updated on ClinicalTrials.gov 2025-08-26