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Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

Study acronym: APPOINT
StatusActive, Not Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 26, 2025 (before its estimated November 30, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary and study completion dates: Nov 30, 2024 to Nov 30, 2025v5
  2. Primary and study completion dates: Jun 30, 2024 to Nov 30, 2024v4
  3. Primary and study completion dates: Oct 2023 to Jun 30, 2024v3
  4. Re-verified, no change to tracked fieldsv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV
Trial Details
NCT Number NCT05853068
Lead Sponsor Hospital Universitario de Gran Canaria Doctor Negrín
Collaborators: Rush University Medical Center
Conditions
(from sponsor)		 Acute Hypoxemic Respiratory Failure
Related terms Respiratory Insufficiency
Enrollment 400 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov