SGLT2 Inhibitor TrEatment iN Patients Awaiting cOronary arTery bYpass Surgery to Reduce Post-opErative AF

The goal of this randomized, double-blinded, controlled clinical trial is to investigate if treatment with an sodium-glucose cotransporter-2 inhibitor (SGLT2) during the unique time window before coronary artery bypass surgery (CABG), can reduce the incidence of post-operative atrial fibrillation and/or acute kidney injury in patients with chronic coronary syndrome. The main questions it aims to answer are: * Does treatment with an SGLT2 inhibitor during the waiting time and stable post-operative period, in patients with chronic coronary syndrome scheduled for CABG, reduce the risk of new onset atrial fibrillation compared to placebo? * Does treatment with an SGLT2 inhibitor during the waiting time and stable post-operative period, in patients with chronic coronary syndrome scheduled for CABG, reduce the risk of acute kidney injury before hospital discharge compared to placebo? Participants will be administered dapagliflozin 10 mg once daily or placebo for a minimum of seven days while awaiting scheduled CABG and up until discharge, with a short interruption for surgery. The active arm will be compared to the placebo arm to see if dapagliflozin can reduce the incidence of post-operative atrial fibrillation and/or acute kidney injury.

NCT Number	NCT05852704
Lead Sponsor	Region Örebro County Collaborators: Odense University Hospital, Aarhus University Hospital, Örebro University, Sweden, Sahlgrenska University Hospital, Göteborg University, University of Leeds, Skane University Hospital, London School of Hygiene and Tropical Medicine, St. Anne's University Hospital Brno, Czech Republic, Mount Sinai Hospital, New York, Icahn School of Medicine at Mount Sinai, University Hospital, Linkoeping, Rigshospitalet, Denmark
Conditions	Chronic Coronary Syndrome, Atrial Fibrillation
Enrollment	800 participants
Start Date	2024-04-04
Primary Completion	2027-12-04 (estimated)
Study Completion	2028-12-04 (estimated)
Updated on ClinicalTrials.gov	2025-04-08