Clinical Trial

Oral Changes With Caloric and no Caloric Sweeteners

Recruiting Phase 1/2
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Record status
This record was last updated October 9, 2025 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.
Summary
The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm microbiome in Mexican adolescents. Participants will drink on different occasions a beverage without sweetener, a beverage added with stevioside or a beverage added with sucrose. The researchers will compare the changes that each one causes in salivary pH, dental biofilm pH, dental biofilm bacterial proliferation and dental biofilm microbiome.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2023-05-05; most recent amendment 2025-10-07.
Status change: Not Yet Recruiting → Recruiting 2025-10-07
Trial Details
NCT Number NCT05852145
Lead Sponsor Hospital Infantil de Mexico Federico Gomez
Conditions pH, Microbiome, Dental Plaque
Enrollment 52 participants
Start Date 2025-08-01
Primary Completion 2025-12 (estimated)
Study Completion 2026-04 (estimated)
Updated on ClinicalTrials.gov 2025-10-09