The Proactive Ophthalmic Examination Cohort

The Proactive Ophthalmic Examination Cohort of Older Adults is a prospective cohort study recruiting community-dwelling older adults aged 65 years or older. Through comprehensive assessment of demographic profiles, medical histories, and ocular structural and functional parameters, alongside systematic collection of ophthalmic and systemic clinical data and biological specimens, we will establish a multidimensional, high-quality ocular health database encompassing demographic characteristics, socioeconomic factors, lifestyle variables, ocular disease risk factors, subjective ocular symptoms, objective examination findings, and biospecimens. The study will investigate the onset and progression patterns of ocular diseases, associated risk factors, and mechanisms of ocular aging in older populations, while simultaneously providing normal-controlled clinical and genomic data for other clinical studies on eye diseases. Furthermore, leveraging algorithmic innovation and artificial intelligence technologies, we will develop a personalized risk prediction and monitoring platform for age-related eye diseases, enhancing early screening and diagnostic capabilities and advancing precision medicine for ocular health in older adults.

NCT Number	NCT05851287
Lead Sponsor	Zhongshan Ophthalmic Center, Sun Yat-sen University
Conditions	Vision Impairment, Eye Diseases
Enrollment	5,000 participants
Start Date	2023-02-20
Primary Completion	2033-02-19 (estimated)
Study Completion	2034-02-19 (estimated)
Updated on ClinicalTrials.gov	2026-06-09