Clinical Trial

Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints

Recruiting Early Phase 1

Summary

The goal of this study is to investigate whether the botanical product kratom affects how the body processes the opioid drug oxycodone. The main research questions to be answered are two-fold: 1. How does kratom affect the manner in which oxycodone is metabolized (broken down and removed) by the body? 2. Does kratom change the effects oxycodone exerts on the body? Healthy adult participants will complete four study arms, during which they will be given the following: * Kratom (as a tea) * A single dose of oxycodone (as a tablet) * Kratom tea and a single dose of oxycodone * Kratom tea for four days, then kratom tea and a single dose of oxycodone

Protocol Amendment History 4 amendments

This ClinicalTrials.gov record has been amended 4 times since 2023-04-26; most recent amendment 2026-06-02.

Status change: Not Yet Recruiting → Recruiting 2023-08-11

Trial Details

NCT Number	NCT05846451
Lead Sponsor	Washington State University Collaborators: National Center for Complementary and Integrative Health (NCCIH)
Conditions	Herbal Interaction
Enrollment	16 participants
Start Date	2023-06-01
Primary Completion	2026-11-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-03