HIIT Effects on Cardiometabolic Health

The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.

NCT Number	NCT05838950
Lead Sponsor	Syracuse University
Conditions	Obesity, Cardiovascular Diseases, Metabolic Disease, High-intensity Interval Training
Enrollment	60 participants
Start Date	2023-09-29
Primary Completion	2025-08-23 (estimated)
Study Completion	2025-12-10 (estimated)
Updated on ClinicalTrials.gov	2025-07-23