This record was last updated December 4, 2024 (before its estimated June 2025 completion). Its status may not reflect the trial's current state.
Summary
The management of septic states includes, in addition to the specific treatment (antimicrobials and eradication of the source), a restoration of the hemodynamic disorders and assistance of the failing organs. In general, the restoration of hemodynamic disorders begins first with volume expansion, followed by the use of Noepinephrine (NE) when the target mean arterial pressure (MAP) is not reached after optimizing the intravascular volume. Recently, several studies have supported the interest of early NE on MAP, cardiac output and mortality. It is therefore tempting to restrict fluid administration even in the initial phase of hemodynamic management of severe sepsis by starting NE earlier.
Protocol Amendment History
4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2023-04-18; most recent amendment 2024-12-02.
Status change: Not Yet Recruiting → Recruiting2023-08-28