Clinical Trial

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

Study acronym: VNS in OUD UH3
Recruiting Phase 3
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Summary
This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, have an MRI scan, and have a follow-up call 1-3 months after their inpatient stay. Participants will complete several psychiatric questionnaires/interviews, physiological monitoring with several devices, brain imaging, and VNS testing.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2023-04-14; most recent amendment 2026-03-24.
Status change: Not Yet Recruiting → Recruiting 2023-10-11
Trial Details
NCT Number NCT05834478
Lead Sponsor Emory University
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Withdrawal Symptoms, Opioid Use Disorder, Opioid Use
Enrollment 103 participants
Start Date 2024-02-20
Primary Completion 2027-02 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-03-27