The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum

The goal of this randomized clinical trial is to assess the effect of etidronate on ectopic calcification in relatively young patients with Pseudoxanthoma elasticum. The main question it aims to answer are: What is the difference in the arterial calcification scores in the legs and the carotid syphon measured on low-dose CT scan after 24 months of treatment compared to baseline between etidronate and placebo. Participants will be asked to do take etidronate or placebo for 24 months.

NCT Number	NCT05832580
Lead Sponsor	UMC Utrecht
Conditions	Pseudoxanthoma Elasticum
Enrollment	76 participants
Start Date	2023-04-26
Primary Completion	2027-03-29 (estimated)
Study Completion	2027-04-29 (estimated)
Updated on ClinicalTrials.gov	2023-04-27