Clinical Trial

Exploring Novel Biomarkers for Emphysema Detection

Study acronym: ENBED
Recruiting
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Record status
This record was last updated June 13, 2025 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.
Summary
The goal of this clinical trial is to evaluate whether voice or capnometry, alone or in combination with other (non invasive) biomarkers can be used to detect emphysema on chest CT-scan in people with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is: • Can a machine-learning based algorithm be developed that can classify the extent of emphysema on chest CT scan from patients with COPD, based on voice and/or capnometry. Participants will: * perform different voice-related tasks * perform capnometry twice (before/after exercise) * perform a light exercise task between tasks ( 5-sit-to-stand test) * undergo one venipuncture
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-04-11; most recent amendment 2025-06-10.
Status change: Not Yet Recruiting → Recruiting 2023-11-21
Trial Details
NCT Number NCT05825261
Lead Sponsor Maastricht University
Collaborators: Roche Pharma AG
Conditions Copd, Emphysema
Enrollment 200 participants
Start Date 2023-09-07
Primary Completion 2025-12 (estimated)
Study Completion 2026-05 (estimated)
Updated on ClinicalTrials.gov 2025-06-13