Carotid Plaque Imaging Project (CPIP)

The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.

NCT Number	NCT05821894
Lead Sponsor	Lund University Collaborators: Region Skane, The Swedish Research Council, Swedish Heart Lung Foundation, Skåne University Hospital funds (incl. the Medical Training and Research Agreement/ALF), Swedish Foundation for Strategic Research
Conditions	Atherosclerosis, Atherosclerotic Plaque
Enrollment	3,500 participants
Start Date	2005-10-26
Primary Completion	2029-12 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2024-10-15