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The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis

StatusRecruiting
PhasePhase 4
Started2024-01-15
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 5, 2025 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.

Amendment history

2025-02-03
Study Status v5
Primary completion date2024-12→2025-12
Completion date2025-02→2026-02
2024-01-09
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v4
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2024-04→2024-12
Completion date2024-11→2025-02
Start date2023-09→2024-01-15
Study sitesdetails revised at 1 of 1 site
2023-08-07
Study Status v3
Start date2023-06→2023-09
2023-05-02
Study Status, Study Description v2
Start date2023-04→2023-06
Study description-40 characters
[...] rations can produce the same systemic effects as oral. Habib et al. reports that systemic side effects increase with the concen [...] fluid. If there is a significant intra-articular effusion, itthe fluid will beby atremoved thevia discretion of the physiatrist whether or not to puncture the fluidpunture prior to injection. This information will be noted on a she [...]
2023-04-26
Study Identification, Study Status, Conditions, Arms and Interventions, Outcome Measures, Eligibility v1
InterventionsAcetonide Triamcinolone (Drug)→Triamcinolone Acetonide (Drug)
Eligibility criteria+45 characters
Inclusion Criteria: Symptomatic primary gonarthrosis of over 6 months duration (gonarthrosis according to the ACRAmerican College of Rheumatology criteria) Grade 1 to 3 Kellgren-Lawrence femorotibial osteo [...] is Knee pain provoked by activity over 4 and under 8 on 10 (VASVisual Analog Scale) Exclusion Criteria: Bilateral symptomatic primary gonarthr [...]
Secondary endpoints3 entries, revised
EVAVAS
Primary endpoints1 entry, revised
WOMAC FonctionFunction
Study title-60 characters
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis: a Non-inferiority Randomized Controlled Double-blind Study
2023-03-28
Original filing
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying degrees of pain. When pain is bothersome, osteoarthritis is treated to improve functional abilities. One of the most recognized and used treatments is intra-articular cortisone injection. Cortisone is a powerful anti-inflammatory drug that is used to reduce pain. Unfortunately, cortisone can have significant side effects, even when injected locally. The frequency and intensity of these side effects depend largely on the total dose injected. The main side effects include increased blood sugar levels, increased blood pressure and a temporary decrease in the secretion of the stress hormone, cortisol. In the long term, a decrease in articular cartilage thickness in the injected join and overall bone density reduction is also reported. Despite many years of routine use, the smallest effective dose of cortisone injected into the knee joint is unknown. The main objective of the study is to determine the impact on pain and function of different doses of cortisone injected into the knee. The cortisone chosen for this study is triamcinolone acetonide (TA).
Trial Details
NCT Number NCT05806021
Lead Sponsor Centre hospitalier de l'Université de Montréal (CHUM)
Conditions Primary Gonarthrosis
Enrollment 327 participants
Start Date 2024-01-15
Primary Completion 2025-12 (estimated)
Study Completion 2026-02 (estimated)
Updated on ClinicalTrials.gov 2025-02-05