Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors

The goal of the proposed study is to compare the efficacy of behavioral treatment (BT) to memantine, a psychopharmacological agent, for BFRBs. 28 subjects with trichotillomania (TTM) or skin picking disorder (SPD) will receive 8 weeks of memantine treatment, followed by 8 weeks of comprehensive behavioral therapy (ComB) treatment. The hypothesis to be tested is that behavioral therapy will be associated with superior clinical outcomes as compared to memantine. A second hypothesis is that both memantine and behavioral therapy will demonstrate improvement from baseline to the respective posttreatment assessment.

NCT Number	NCT05796752
Lead Sponsor	University of Chicago
Conditions	Skin-Picking, Trichotillomania (Hair-Pulling Disorder)
Enrollment	26 participants
Start Date	2023-08-02
Primary Completion	2026-04-16 (estimated)
Study Completion	2027-06 (estimated)
Updated on ClinicalTrials.gov	2026-07-07