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Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)

StatusRecruiting
PhasePhase 2
Started
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Record status
This record was last updated March 26, 2025 (before its estimated November 1, 2025 completion). Its status may not reflect the trial's current state.

Record History

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  1. Trial status: Not Yet Recruiting to Recruitingv3 Show 9 more changesShow less
    • Primary completion date: May 1, 2025 to Nov 1, 2025
    • Start date changed from estimate of Apr 1, 2023 to Nov 1, 2023
    • Primary endpoint revised
    • Enrollment target: 168 to 160
    • Study completion date: Sep 1, 2025 to Feb 1, 2026
    • Secondary endpoints: 8 to 12
    • Site details revised
    • Publications: 1 to 2
    • Eligibility criteria expanded, about 2 words
  2. Secondary endpoints revised (8)v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.
Trial Details
NCT Number NCT05789823
Lead Sponsor Capital Medical University
Conditions
(from sponsor)		 Acute Ischemic Stroke
Related terms Ischemic Stroke
Enrollment 160 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov