Clinical Trial

Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)

Recruiting Phase 2
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Record status
This record was last updated March 26, 2025 (before its estimated November 1, 2025 completion). Its status may not reflect the trial's current state.
Summary
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-03-16; most recent amendment 2025-03-21.
Status change: Not Yet Recruiting → Recruiting 2025-03-21
Trial Details
NCT Number NCT05789823
Lead Sponsor Capital Medical University
Conditions Acute Ischemic Stroke
Enrollment 160 participants
Start Date 2023-11-01
Primary Completion 2025-11-01 (estimated)
Study Completion 2026-02-01 (estimated)
Updated on ClinicalTrials.gov 2025-03-26