Energy Metabolism Profiles Over Weight-loss and Eating Responses

This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese. Twelve weeks of caloric-restriction dietary intervention will be conducted in the overweight or obese participants. Before and after the 12-week intervention, metabolic health will be characterized by metabolic homeostasis, determined via comprehensive measurements of dynamic postprandial metabolic responses to a standardized mixed macronutrient tolerance test (75 g glucose, 60 g fat, 20 g protein) in a whole-room indirect calorimeter. The objectives of this study are 1. to characterize dynamic metabolic response elicited by acute nutritional and acute exercise challenges, 2. to elucidate biological mechanisms underlying inter-individual heterogeneity in these responses, 3. to predict prospective weight loss over the intervention using heterogeneous metabolic responses to acute challenges

NCT Number	NCT05785221
Lead Sponsor	Chinese Academy of Sciences Collaborators: Sir Run Run Shaw Hospital
Conditions	Homeostasis, Metabolism and Nutrition Disorder, Healthy, Obesity
Enrollment	117 participants
Start Date	2023-03-02
Primary Completion	2025-03-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-09