Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma

With 50 patients included, this trial would be the largest pilot study evaluating the value of MRI PET in locally advanced rectal cancer. On the other hand, it would be the only pilot study performing several MRI PET during neoadjuvant treatment. Presumably, the response assessed at the 2nd MRI PET (before cycle 4 or induction chemotherapy) would be predictive of the overall response at the end of neoadjuvant treatment. Then, it would be possible to predict precociously the tumor response.

NCT Number	NCT05772481
Lead Sponsor	Centre Paul Strauss
Conditions	Rectal Cancer
Enrollment	50 participants
Start Date	2023-05-19
Primary Completion	2026-09-18 (estimated)
Study Completion	2026-09-18 (estimated)
Updated on ClinicalTrials.gov	2026-06-05