Bimanual Motor Skill Learning in Acute Stroke

The subacute phase of stroke provides a window into how a lesion perturbs sensorimotor functions prior to reorganisation driven by plasticity and neurorehabilitation. The recovery from motor impairment has been extensively studied, but it is currently unknown whether motor skill learning (MSkL) is enhanced or impaired during acute stroke, especially bimanual motor skill learning (bim-MSkL), which likely requires more motor-attentional-cognitive resources than unimanual MSkL. The goals of this project are: to determine the neural substrates critical to achieve proximal and distal bimanual motor skill learning (bim-MSkL) by specifying whether (sub)acute stroke to different brain areas (cortical and subcortical) induce specific deficits in bimanual and/or distal bim-MSkL, which behavioral components are involved in bim-MSkL, and whether damage to the motor, sensory and inter-hemispheric pathways specifically impairs proximal and/or distal bim-MSkL.

NCT Number	NCT05760846
Lead Sponsor	University Hospital of Mont-Godinne
Conditions	Stroke, Acute, Stroke, Subacute
Enrollment	160 participants
Start Date	2023-04-17
Primary Completion	2028-03 (estimated)
Study Completion	2028-10 (estimated)
Updated on ClinicalTrials.gov	2026-08-12