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REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry

Study acronym: REPOSE-2
StatusRecruiting
PhasePhase 4
Started2023-04-03
View on ClinicalTrials.gov ↗

Amendment history

2025-08-19
Study Status, Contacts/Locations v2
Primary completion date2024-12-31→2027-12-31
Study sites17→44
2023-04-06
Not Yet Recruiting→Recruiting Study Status, Eligibility, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2023-03-01→confirmed 2023-04-03
Study sites1→17
Eligibility criteria+164 characters
[...] SA score ≥5; Exposure to general anesthesia in prior 30 days or anticipated re-exposure to general anesthesia within 30 days after surgery; Need for prolonged airway protection or mechanical ventilatory support after surgery; Current participation in another interventional study; Previ [...]
2023-02-06
Original filing
The goal of this randomized controlled trial is to compare total intravenous anesthesia with remimazolam vs total intravenous anesthesia with propofol in moderate-to-high risk patients undergoing major elective noncardiac surgery under general anesthesia. The primary hypothesis is that total intravenous anesthesia with remimazolam can increase days alive and out of hospital at postoperative day 30 compared with total intravenous anesthesia with propofol.
Trial Details
NCT Number NCT05728775
Lead Sponsor Nanfang Hospital, Southern Medical University
Conditions Anesthesia, Surgery-Complications
Enrollment 7,188 participants
Start Date 2023-04-03
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-08-26