Clinical Trial

REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry

Study acronym: REPOSE-2
Recruiting Phase 4
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Summary
The goal of this randomized controlled trial is to compare total intravenous anesthesia with remimazolam vs total intravenous anesthesia with propofol in moderate-to-high risk patients undergoing major elective noncardiac surgery under general anesthesia. The primary hypothesis is that total intravenous anesthesia with remimazolam can increase days alive and out of hospital at postoperative day 30 compared with total intravenous anesthesia with propofol.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-02-06; most recent amendment 2025-08-19.
Status change: Not Yet Recruiting → Recruiting 2023-04-06
Trial Details
NCT Number NCT05728775
Lead Sponsor Nanfang Hospital, Southern Medical University
Conditions Anesthesia, Surgery-Complications
Enrollment 7,188 participants
Start Date 2023-04-03
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-08-26