Clinical Trial

Intravenous Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Stroke

Study acronym: ADJUVANT
Recruiting Phase 2/3
View on ClinicalTrials.gov →
Record status
This record was last updated December 26, 2025 (before its estimated February 28, 2026 completion). Its status may not reflect the trial's current state.
Summary
In patients with acute ischemic stroke secondary to large vessel occlusion, the role of intravenous adjunctive medications, such as tirofiban, or alteplase before endovascular thrombectomy has not been well investigated. This trial aim to evaluate the efficacy and safety of intravenous tirofiban versus alteplase for acute ischemic stroke patients with large vessel occlusion piror to endovascular thrombectomy.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-02-14; most recent amendment 2025-12-18.
Status change: Not Yet Recruiting → Recruiting 2023-12-27
Trial Details
NCT Number NCT05728333
Lead Sponsor Xinqiao Hospital of Chongqing
Collaborators: Zhejiang University
Conditions Stroke, Acute Ischemic
Enrollment 800 participants
Start Date 2023-11-28
Primary Completion 2026-02-28 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-26