Psilocybin in Functional Neurological Disorder

The goal of this study is to learn about the brain network response in people who have functional neurological disorder who are administered with a single dose of the psychedelic psilocybin with therapeutic support. The main question it aims to answer is: Can the default mode network, a brain network thought to be relevent in FND, be modified by the administration of psilocybin based on functional magnetic resonance imaging before and after the dose?

NCT Number	NCT05723276
Lead Sponsor	King's College London
Conditions	Functional Neurological Disorder
Enrollment	20 participants
Start Date	2024-02-14
Primary Completion	2026-04-14 (estimated)
Study Completion	2026-07-07 (estimated)
Updated on ClinicalTrials.gov	2026-07-23