Clinical Trial

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

Study acronym: CARES
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2023-02-09; most recent amendment 2026-04-13.
Trial Details
NCT Number NCT05722002
Lead Sponsor University of Michigan
Collaborators: Patient-Centered Outcomes Research Institute
Conditions Surgery, Pain, Postoperative
Enrollment 900 participants
Start Date 2023-02-06
Primary Completion 2026-12 (estimated)
Study Completion 2027-07 (estimated)
Updated on ClinicalTrials.gov 2026-04-17