Clinical Trial

Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

Study acronym: STOP-TIC

Recruiting

Record status

This record was last updated July 18, 2025 (before its estimated March 30, 2026 completion). Its status may not reflect the trial's current state.

Summary

This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.

Protocol Amendment History 4 amendments

This ClinicalTrials.gov record has been amended 4 times since 2023-01-21; most recent amendment 2025-07-15.

Status change: Not Yet Recruiting → Recruiting 2023-07-24

Trial Details

NCT Number	NCT05705999
Lead Sponsor	West Virginia University Collaborators: University of Florida, Tourette Association of America
Conditions	Tourette Syndrome
Enrollment	20 participants
Start Date	2024-03-12
Primary Completion	2026-03-30 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-07-18