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Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 16, 2025 (before its estimated September 28, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary and study completion dates: Sep 28, 2025 to Sep 28, 2026 Site details revised at 1 of 4 sitesv5 Show 1 more changeShow less
    • Site details revised at 1 of 4 sites
  2. Primary and study completion dates: Sep 28, 2024 to Sep 28, 2025 Site details revised at 2 of 4 sitesv4 Show 1 more changeShow less
    • Site details revised at 2 of 4 sites
  3. Site details revised at 3 of 4 sitesv3
  4. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of May 1, 2023 to Sep 29, 2023 · Study sites: 1 to 4v2 Show 2 more changesShow less
    • Start date changed from estimate of May 1, 2023 to Sep 29, 2023
    • Study sites: 1 to 4
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow. We previously studied the safety of subconjunctival injection of allogeneic bone marrow-derived MSCs in patients with nonhealing epitheliopathy (IRB Protocol 2020-0334). In the present study, we want to study the efficacy of this treatment on chronic epitheliopathies.
Trial Details
NCT Number NCT05705024
Lead Sponsor University of Illinois at Chicago
Collaborators: United States Department of Defense
Conditions Corneal Ulcer
Enrollment 38 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov