Clinical Trial

Using the Ending Self-Stigma Intervention to Reduce Internalized Stigma Among People Living With HIV Who Use Substances

Study acronym: IRIS
Active, Not Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated July 20, 2025 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this clinical trial is to test an intervention to reduce stigma among people living with HIV who use opioids and cocaine. The main question it aims to answer is: \- Does reducing internalized stigma about HIV and/or drug use lead to improved HIV care outcomes? After a year spent adapting an existing intervention to be applied specifically among people living with HIV who use substances, 70 participants will be randomized to receive either treatment-as-usual or the newly adapted intervention. The intervention itself will consist of five one-on-one sessions with a trained interventionist to discuss and work through the stigmas people commonly associate with HIV and/or substance use.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2023-01-20; most recent amendment 2025-07-16.
Status change: Enrolling by Invitation → Active, Not Recruiting 2025-03-16
Trial Details
NCT Number NCT05704764
Lead Sponsor Friends Research Institute, Inc.
Collaborators: University of Maryland, National Institute on Drug Abuse (NIDA), Johns Hopkins University
Conditions HIV, Stigma, Social, Substance Use
Enrollment 70 participants
Start Date 2023-02-17
Primary Completion 2026-03-31 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-07-20