Switching to E-cigarettes in Smokers Not Interested in Quitting

The objectives of this application are to 1) compare short- and long-term harm reduction and abuse liability potential of a nicotine salt pod-based electronic cigarettes (EC) in adult (AA) exclusive EC, dual cig-EC, and exclusive cig users, 2) characterize factors that predict who switches fully, partially, or not at all, and 3) examine if harm reduction can be further enhanced by treating dual users with varenicline (VAR) to eliminate cigarette smoking.

NCT Number	NCT05703672
Lead Sponsor	University of Kansas Medical Center
Conditions	Smoking Reduction
Enrollment	500 participants
Start Date	2023-07-17
Primary Completion	2026-12-07 (estimated)
Study Completion	2027-02-28 (estimated)
Updated on ClinicalTrials.gov	2025-12-29