Clinical Trial

Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study

Active, Not Recruiting Phase 2/3
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Summary
The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowering glaucoma medications are used to treat glaucoma. A total of up to 188 participants will be enrolled and randomized 1:1 to receive N\&P or placebo for 87 weeks (20 months). Participants will be followed for a total of 91 weeks (21 months).
Protocol Amendment History 9 amendments
This ClinicalTrials.gov record has been amended 9 times since 2023-01-13; most recent amendment 2026-07-13.
Status change: Recruiting → Active, Not Recruiting 2025-11-10
Trial Details
NCT Number NCT05695027
Lead Sponsor Columbia University
Collaborators: Stanford University
Conditions Primary Open Angle Glaucoma
Enrollment 250 participants
Start Date 2023-03-14
Primary Completion 2027-08 (estimated)
Study Completion 2028-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-15