Comparing Perioperative Outcomes in Pain Control

This project consists of a randomized controlled study design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have an orthopaedic injury requiring surgery. Patients who consent to study participation will be randomized to receive either the multimodal pain management protocol or standard oral hydrocodone-acetaminophen for post-operative pain management. Data on opioid usage, pain control, and functional status will be collected for each participant. After 3 years of data collection, investigators will analyze this data to provide further insight in determining appropriateness of pain regimens that reduce the overall opioid consumption. Given the widespread opioid epidemic, it is imperative to develop alternative means to appropriately manage pain in orthopaedic surgery patients.

NCT Number	NCT05690282
Lead Sponsor	University of California, San Diego
Conditions	Post-operative Pain
Enrollment	100 participants
Start Date	2021-05-17
Primary Completion	2024-12-31 (estimated)
Study Completion	2026-05-17 (estimated)
Updated on ClinicalTrials.gov	2025-04-24