Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA

Protective ventilatory strategy should be applied to reduce ventilator-induced lung injury (VILI) after Lung Transplantation (LTx) or in case of acute respiratory failure requiring invasive mechanical ventilation. Neurally Adjusted Ventilatory Assist (NAVA) is an assisted ventilation mode in which respiratory support is coordinated by the electrical activity of the diaphragm (EAdi). Aim of the study is to assess the physiological relationship between neural respiratory drive, as assessed by EAdi, and tidal volume, driving pressure, and mechanical power, at different levels of ventilatory assist, in the absence of pulmonary vagal afferent feedback or during acute respiratory failure. Additional parameters will be collected: Pmus, Pocc, transpulmonary pressure etc.

NCT Number	NCT05689476
Lead Sponsor	University of Padova
Conditions	Work of Breathing, Lung Transplantation, Neurally Adjusted Ventilatory Assist, Ventilator-Induced Lung Injury, Acute Respiratory Failure (ARF)
Enrollment	40 participants
Start Date	2022-12-27
Primary Completion	2025-12-27 (estimated)
Study Completion	2025-12-27 (estimated)
Updated on ClinicalTrials.gov	2025-07-08